Maintenance
What clinical trials and real-world studies show about life after the active weight-loss phase — including the ATTAIN-MAINTAIN trial and the Cleveland Clinic's 8,000-patient real-world data on stopping a GLP-1.
5 articles
Maintenance
What the ATTAIN-MAINTAIN trial tells us about GLP-1 maintenance
For most people starting a GLP-1, the conversation is about getting to goal weight. The ATTAIN-MAINTAIN trial asked what comes after — and the data offer a partial but meaningful answer.
4 min · Updated 2026-05-27
Maintenance
You’ve hit your GLP-1 goal weight. Here are the questions to ask your prescriber next.
Hitting your target weight on a GLP-1 is not the end of the conversation. Here are specific questions to raise with your prescriber before you change your plan.
5 min · Updated 2026-05-27
Maintenance
Weight regain after stopping a GLP-1: what the evidence shows
A 2026 Lancet meta-regression found patients regained about 60% of prior weight loss within one year of stopping a GLP-1. Here's what the data actually show — and what long-term planning looks like.
4 min · Updated 2026-05-27
Maintenance
GLP-1 maintenance after weight loss
What the published evidence (and the open questions) say about maintaining weight loss after GLP-1 therapy, and how to plan with your clinician.
12 min · Updated 2026-05-27
Maintenance
What happens to your weight when you stop a GLP-1? A real-world study of nearly 8,000 patients
A Cleveland Clinic study of 7,938 patients found 45% of obesity patients kept weight off a year after stopping semaglutide or tirzepatide. Here's what the evidence actually shows.
5 min · Updated 2026-05-27