Maintenance
What clinical trials and real-world studies show about life after the active weight-loss phase — including the ATTAIN-MAINTAIN trial and the Cleveland Clinic's 8,000-patient real-world data on stopping a GLP-1.
10 articles
Maintenance
GLP-1 persistence has nearly doubled since 2021 — what the research shows
A new JMCP study finds 1-year GLP-1 persistence increased from 33.2% in 2021 to 60.9% in 2024. Here's what's driving the shift — and what it means for patients.
5 min · Updated 2026-07-06
Maintenance
Who stops a GLP-1 — and who comes back: what a 60,000-patient study found
A 60,000-patient ENDO 2026 study found 4 in 10 people stop a GLP-1 within a year — and more than half eventually restart. Here's what the data shows.
6 min · Updated 2026-07-06
Maintenance
Stopping a GLP-1: what the evidence says about weight regain
A 2026 BMJ systematic review found that most people regain the majority of their lost weight within about 18 months of stopping a GLP-1 medication. Here's what…
5 min · Updated 2026-06-08
Maintenance
What stopping a GLP-1 medication means for your cardiovascular health
A 333,000-patient study found stopping GLP-1 treatment is linked to a significant increase in cardiovascular risk. Here's what the evidence shows — and what it means for the discontinuation conversation.
7 min · Updated 2026-06-01
Maintenance
SURMOUNT-MAINTAIN: what a lower tirzepatide dose actually does to weight maintenance
SURMOUNT-MAINTAIN (The Lancet, May 2026) found that stepping down to 5 mg tirzepatide maintained most weight loss compared to full regain on placebo. Here's what the data actually show.
6 min · Updated 2026-05-28
Maintenance
Weight regain after stopping a GLP-1: what the evidence shows
A 2026 Lancet meta-regression found patients regained about 60% of prior weight loss within one year of stopping a GLP-1. Here's what the data actually show — and what long-term planning looks like.
4 min · Updated 2026-05-27
Maintenance
GLP-1 maintenance after weight loss
What the published evidence (and the open questions) say about maintaining weight loss after GLP-1 therapy, and how to plan with your clinician.
12 min · Updated 2026-05-27
Maintenance
What happens to your weight when you stop a GLP-1? A real-world study of nearly 8,000 patients
A Cleveland Clinic study of 7,938 patients found 45% of obesity patients kept weight off a year after stopping semaglutide or tirzepatide. Here's what the evidence actually shows.
5 min · Updated 2026-05-27
Maintenance
You’ve hit your GLP-1 goal weight. Here are the questions to ask your prescriber next.
Hitting your target weight on a GLP-1 is not the end of the conversation. Here are specific questions to raise with your prescriber before you change your plan.
5 min · Updated 2026-05-27
Maintenance
What the ATTAIN-MAINTAIN trial tells us about GLP-1 maintenance
For most people starting a GLP-1, the conversation is about getting to goal weight. The ATTAIN-MAINTAIN trial asked what comes after — and the data offer a partial but meaningful answer.
4 min · Updated 2026-05-27